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AKA-75
Pomalidomide
Cat. No.
AKA-75
CAS No.
19171-19-8
MF
C13H11N3O4
MW
273.24
Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue.
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Technical Data
Description
Storage and Shipping
References
Product Name
Pomalidomide
CAS No.
19171-19-8
MF
C13H11N3O4
MW
273.24
Specification
98%
Research Area
Intermediate
Description
Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Packing: 10mg, 20mg, 50mg, 100mg, 500mg, 1g, 5g, 10g, 1kg Availability: In Stock
Documents
Certificate of Analysis (COA), API specification, Safety Data Sheet (SDS/MSDS), evidence of GMP compliance, Stability data / Stability summary, etc.
Storage and Shipping
Store in a cool & dry place, keep away from strong light and heat.
References
[1]. Zhu YX, et al. Molecular mechanism of action of the immune-modulatory drugs, thalidomide, lenalidomide and pomalidomide in multiple myeloma. Leukemia & Lymphoma. 2013 Apr;54(4):683-7.
[2]. Hernandez-Ilizaliturri FJ, et al. Immunomodulatory drug CC-5013 or CC-4047 and rituximab enhance antitumor activity in a severe combined immunodeficient mouse lymphoma model. Clinical Cancer Research. 2005 Aug 15;11(16):5984-92.
[3]. Schafer PH, et al. Enhancement of cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs. The Journal of Pharmacology and Experimental Therapeutics. 2003 Jun;305(3):1222-32.
[4]. Li Z, et al. Pomalidomide shows significant therapeutic activity against CNS lymphoma with a major impact on the tumor microenvironment in murine models. PloS One. 2013 Aug 5;8(8):e71754.
[5]. Lu J, et al. Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4. Chemistry & Biology. 2015 Jun 18;22(6):755-63.
[6]. Liu D, et al. Tumour necrosis factor-α inhibits hepatic lipid deposition through GSK-3β/β-catenin signaling in juvenile turbot (Scophthalmus maximus L.). General and Comparative Endocrinology. 2016 Mar 1;228:1-8.
[2]. Hernandez-Ilizaliturri FJ, et al. Immunomodulatory drug CC-5013 or CC-4047 and rituximab enhance antitumor activity in a severe combined immunodeficient mouse lymphoma model. Clinical Cancer Research. 2005 Aug 15;11(16):5984-92.
[3]. Schafer PH, et al. Enhancement of cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs. The Journal of Pharmacology and Experimental Therapeutics. 2003 Jun;305(3):1222-32.
[4]. Li Z, et al. Pomalidomide shows significant therapeutic activity against CNS lymphoma with a major impact on the tumor microenvironment in murine models. PloS One. 2013 Aug 5;8(8):e71754.
[5]. Lu J, et al. Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4. Chemistry & Biology. 2015 Jun 18;22(6):755-63.
[6]. Liu D, et al. Tumour necrosis factor-α inhibits hepatic lipid deposition through GSK-3β/β-catenin signaling in juvenile turbot (Scophthalmus maximus L.). General and Comparative Endocrinology. 2016 Mar 1;228:1-8.
Disclaimer
This product is intended solely for scientific research or regulatory filing purposes. We do not provide products or services to individuals, please strictly comply with all applicable laws, regulations, and the committed use. Use for any other purpose is strictly prohibited.
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